Effect of pH on Biological Activity of Chorionic Gonadotropin

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Science  26 Jun 1959:
Vol. 129, Issue 3365, pp. 1738
DOI: 10.1126/science.129.3365.1738


Increasing the pH from 3.0 to 10.8 increased the uterine weight three-fold and the number of positive vaginal smears from 0 to 78 percent in immature rats injected with chorionic gonadotropin in aqueous solution. Activity of a solution held at pH 2.6 and 5°C for 24 hours was restored by neutralization.