Bilirubin Inhibition of Heme Biosynthesis

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Science  26 Jun 1959:
Vol. 129, Issue 3365, pp. 1741-1742
DOI: 10.1126/science.129.3365.1741


The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of this finding in hyperbilirubinemia are mentioned.