Molecular Structural Factors in Competitive Inhibition of Sugar Transport

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Science  10 Jul 1959:
Vol. 130, Issue 3367, pp. 104-105
DOI: 10.1126/science.130.3367.104


The high potency of phloretin as a competitive inhibitor of the human red cell's monosaccharide transport system is not shared by any of several molecular fragments of phloretin, but is duplicated in certain artificial estrogens resembling phloretin in respect to the spacing between terminal phenolic —OH groups. Related molecules which are slightly less extendible are comparatively inactive.