Role of Water in the Stability of Oxyhemoglobin

Science  17 Jul 1959:
Vol. 130, Issue 3368, pp. 164
DOI: 10.1126/science.130.3368.164


Electron exchange involving the valence states of iron occurs via water bridges. Molecular oxygen reversibly displaces the sole coordinated water of the ferrous iron in hemoglobin, and, in the absence of this ready path for electron transfer, the oxygen is transported without oxidation of the ferrous iron of hemoglobin.