Inhibition of O-Methyltransferase by Catechol and Sensitization to Epinephrine

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Science  21 Aug 1959:
Vol. 130, Issue 3373, pp. 453-454
DOI: 10.1126/science.130.3373.453


Catechol at equimolecular concentration inhibits the inactivation of adrenaline by O-methyltransferase in vitro about 50 percent. The inhibition is probably responsible for the sensitization of smooth muscles to epinephrine by various ortho di- or triphenols.