Monoamine Oxidase, Psychoenergizers, and Tranquilizers

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Science  28 Aug 1959:
Vol. 130, Issue 3374, pp. 500
DOI: 10.1126/science.130.3374.500


1-Benzyl-2-methyl-5-methoxytryptamine (BAS) inhibits monoamine oxidase in man. This finding confirms the findings of Woolley in mice. Since BAS, a tranquilizing agent, and Marsilid, a psychoenergizer, are both monoamine oxidase inhibitors, doubt is cast upon the hypothesis, that the stimulatory effect of Marsilid is due to its ability to inhibit monoamine oxidase.