Decrease in Threshold without Depolarization in Cyanide-Treated Muscle

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Science  04 Sep 1959:
Vol. 130, Issue 3375, pp. 572-573
DOI: 10.1126/science.130.3375.572-a


When smooth muscle of Mytilus is treated with relatively weak solutions of sodium cyanide, a transitory hyperpolarization or no change in polarization precedes final depolarization. Thresholds for thermal, chemical, and electrical stimulation are all decreased during this period. Strength-duration curves indicate a reversible decrease in threshold of about 50 percent during this period.