Potentiation of Epinephrine and Norepinephrine by Iproniazid

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Science  18 Sep 1959:
Vol. 130, Issue 3377, pp. 710-711
DOI: 10.1126/science.130.3377.710


The effects of pretreatment with iproniazid on the toxicity and cataract-producing ability of epinephrine and norepinephrine were studied. The epinephrine and norepinephrine were administered in such a way that a slow, prolonged rate of absorption was achieved. Under these conditions, the lethality and cataract-producing ability of these amines were shown to be significantly enhanced by the action of iproniazid.