Inhibitor of O-Methylation of Epinephrine and Norepinephrine in vitro and in vivo

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Science  25 Sep 1959:
Vol. 130, Issue 3378, pp. 800
DOI: 10.1126/science.130.3378.800


Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse. Since pyrogallol also prolongs the physiological effects of epinephrine, it is suggested that catechol-O-methyl transferase terminates the actions of the catecholamine hormones.