Experimental Evidence in Support of the Dormant Tumor Cell

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Science  09 Oct 1959:
Vol. 130, Issue 3380, pp. 918-919
DOI: 10.1126/science.130.3380.918


When rats were injected intraportally with as few as 50 Walker-256 carcinosarcoma cells aarcoma cells and then examined 5 months later for hepatic tumor growth, none was evident. If, however, 3 months after injection the rats were subjected to repeated laparotomy and liver examination at 7-day intervals, 100 percent had a tumor within a few weeks.