Effects on Palate Development of Mechanical Interference with the Fetal Environment

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Science  16 Oct 1959:
Vol. 130, Issue 3381, pp. 981
DOI: 10.1126/science.130.3381.981


Operations employing various combinations of amniotic fluid withdrawal and release of the embryo from enveloping membranes were performed just prior to the time of normal palate closure. Observations on subsequent palate development led to the hypothesis that fetal membranes can compress the fetus and cause cleft palate when pressure in the amniotic sac is reduced.