Induction of the Respiration-Deficient Mutation in Yeast by Various Synthetic Dyes

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Science  30 Oct 1959:
Vol. 130, Issue 3383, pp. 1188-1189
DOI: 10.1126/science.130.3383.1188-a


Series of triphenylmethane and xanthene dyes were found to be effective as inducers of respiration-deficient mutation in yeast. The quantitative difference in the mutagenic effect appeared to be in close relationship to the chemical structure of the respective dyes. This survey may provide a useful clue for elucidation of the mechanism of mutagenic induction.