Enzymatic Factors in Experimental Galactose Cataract

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Science  27 Nov 1959:
Vol. 130, Issue 3387, pp. 1473-1474
DOI: 10.1126/science.130.3387.1473-a


In the rat lens, glucose-6-phosphate dehydrogenase activity is specifically inhibited by galactose-l-phosphate, both in vitro and in vivo. In galactose-fed animals this inhibition occurs prior to the apparent inhibition of soluble protein synthesis in the ocular lens.