Induced Synthesis of Liver Microsomal Enzymes Which Metabolize Foreign Compounds

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Science  27 Nov 1959:
Vol. 130, Issue 3387, pp. 1478-1479
DOI: 10.1126/science.130.3387.1478


The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.