Method for the Study of Antigenicity of Homologous Whole Spleen Cells in Mice

See allHide authors and affiliations

Science  18 Dec 1959:
Vol. 130, Issue 3390, pp. 1707-1708
DOI: 10.1126/science.130.3390.1707


A method for the quantitative assay of the antigenicity of homologous mouse whole spleen cells in the system of A/Heston (donor) to C57BL/6 (recipient) is described. The assay is based upon the graded response of skin homografts to the numbers of donor cells injected intraperitoneally into the recipient prior to the skin graft. The response is linear with respect to the logarithm (base 10) of the number of cells injected.