Mitotic Arrest by Deuterium Oxide

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Science  01 Jan 1960:
Vol. 131, Issue 3392, pp. 37-39
DOI: 10.1126/science.131.3392.37


In marine invertebrate eggs, where cell divisions occur without growth, deuterium oxide produces arrest of, or serious delay in, mitosis and cytokinesis. All stages requiring assembly or operation of mechanical structures in the cytoplasm are sensitive to D.O. The block is reversible in some cells.