Enzymatic Basis of Mannose Toxicity in Honey Bees

See allHide authors and affiliations

Science  29 Jan 1960:
Vol. 131, Issue 3396, pp. 297-298
DOI: 10.1126/science.131.3396.297


Honey bees have a negligible amount of phosphomannoseisomerase, together with a high content of a hexokinase which phosphorylates mannose more efficiently than fructose or glucose. Competition at the phosphorylation level plus accumulation of mannose-6-phosphate can fully account for the toxicity of mannose in honey bees.