Induction of Ovulation in Immature Hypophysectomized Rats

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Science  05 Feb 1960:
Vol. 131, Issue 3397, pp. 357-359
DOI: 10.1126/science.131.3397.357


Immature rats given minute doses of highly purified pituitary gonadotropins (follicle-stimulating hormone and luteinizing hormone) 7 to 100 days after hypophysectomy ovulated and formed corpora lutea. Neither hormone alone was effective. Luteinizing hormone repaired in part the atrophied theca interna and interstitial tissue, and follicle-stimulating hormone stimulated the development of the granulosa cells.