Characteristics of Blood-Brain Barrier to Gamma-Aminobutyric Acid in Neonatal Cat

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Science  12 Feb 1960:
Vol. 131, Issue 3398, pp. 410-412
DOI: 10.1126/science.131.3398.410


Systemic γ-aminobutyric acid produces a rapid, sustained, but transiently reversible blockade of evoked axodendritic excitatory postsynaptic potentials in neonatal cortex when the "barrier" operating to restrict its passage has been altered by various experimental procedures. The data obtained under these conditions indicate the existence of well-developed synaptic pathways in the superficial neuropil of immature cortex.