Acyl N → O Shift in Poly-DL-Serine

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Science  12 Feb 1960:
Vol. 131, Issue 3398, pp. 420-421
DOI: 10.1126/science.131.3398.420


It has been demonstrated that concentrated sulfuric acid causes the polypeptide, poly-DL-serine (MW≈5000), to rearrange to the polyester, to the extent of 70 percent of the original number of amide bonds. The remaining hydroxyls of the serine residues become sulfonated.