Serine Derivative with Antitumor Activity

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Science  04 Mar 1960:
Vol. 131, Issue 3401, pp. 666
DOI: 10.1126/science.131.3401.666


The sodium salt of N-dichloroacetyl-DL-serine depresses the growth of sarcoma-37 in mice, causing complete regressions of the tumor. The compound is nontoxic to mice in doses up to 4 gm/kg of body weight. The animals do not lose body weight and show no alteration in the formed elements of the blood or in hemoglobin content.