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The Error Hypothesis of Mutation

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Science  11 Mar 1960:
Vol. 131, Issue 3402, pp. 730
DOI: 10.1126/science.131.3402.730

Abstract

Accumulation of mutants in glucose-limited chemostats is proportional to growth rate, while in tryptophan-limited chemostats it is independent of growth rate. This behavior, which implies the failure of the error hypothesis, may be explainable on the basis of a unitary hypothesis: the results with glucose may be due to reversion or loss of latent mutants.

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