A Nonsteroidal Androgen

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Science  15 Apr 1960:
Vol. 131, Issue 3407, pp. 1096
DOI: 10.1126/science.131.3407.1096


2-Acetyl-7-oxo-1, 2, 3, 4, 4a, 4b, 5, 6, 7, 9, 10, lOa-dodecahydrophenanthrene possesses androgenic activity when applied directly to the chick's comb. This action is in addition to the antiandrogenic activity previously reported for this compound. This is the first demonstration of androgenic activity by a compound not possessing the steroid nucleus.