Enzymatic O-Methylation of N-Acetylserotonin to Melatonin

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Science  29 Apr 1960:
Vol. 131, Issue 3409, pp. 1312
DOI: 10.1126/science.131.3409.1312


An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.