Is Reserpine Tranquilization Linked to Change in Brain Serotonin or Brain Norepinephrine?

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Science  13 May 1960:
Vol. 131, Issue 3411, pp. 1440-1442
DOI: 10.1126/science.131.3411.1440


Reserpine, when administered to animals stressed by exposure to cold, does not induce sedation or appreciably lower brain serotonin, but markedly lowers brain norepinephrine. Reserpine in cold-exposed hypophysectomized rats elicits sedation and releases both amines equally. The results support the view that the tranquilizing action of reserpine is not related to brain norepinephrine loss but rather to change in the level of brain serotonin.