Rapid Induction of Allergic Encephalomyelitis in Rats without the Use of Mycobacteria

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Science  13 May 1960:
Vol. 131, Issue 3411, pp. 1448
DOI: 10.1126/science.131.3411.1448


Rats, in contrast to certain other species of animals reported, have a striking capacity to develop allergic encephalomyelitis within 2 to 3 weeks following one injection of spinal cord antigen combined with Freund's incomplete adjuvant—that is, adjuvant prepared without addition of killed mycobacteria.