Induced Phenotypic Resistance to an Antimetabolite

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Science  13 May 1960:
Vol. 131, Issue 3411, pp. 1449
DOI: 10.1126/science.131.3411.1449


Resistance to bacteriostasis by 2-thiazole alanine develops rapidly; however, such resistance is lost during growth in the absence of the analog. This induced resistance is accompanied by increased formation of an enzyme sensitive to 2-thiazole alanine. Maintenance of the elevated enzyme levels in growing cells, like resistance, requires the presence of the analog.