Reports

In vitro Studies of Single Isolated Beating Heart Cells

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Science  03 Jun 1960:
Vol. 131, Issue 3414, pp. 1674-1675
DOI: 10.1126/science.131.3414.1674

Abstract

Rat heart cells, separated by trypsin treatment and grown attached to glass in a liquid medium, exhibit periodic contractions similar to a whole beating heart. The rate of beating, which is up to 150 beats per minute, is affected by cardiac drugs and by metabolic substrates and inhibitors.