New Quaternary Ammonium Compounds with Adrenomimetic Action

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Science  24 Jun 1960:
Vol. 131, Issue 3417, pp. 1885-1886
DOI: 10.1126/science.131.3417.1885


Quaternary salts of two triesters of p-dimethylaminothiophenol and phosphoric acid or thiophosphoric acid have effects similar to epinephrine on blood pressure, heart rate, and the nictitating membrane of the anesthetized cat. Two analogous compounds derived from phenol are depressor. None is a potent anticholinesterase. Further investigation is desirable because of the possibility of a relatively specific action on sympathetic ganglia.