Induced Somatic Mutations Affecting Erythrocyte Antigens

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Science  24 Jun 1960:
Vol. 131, Issue 3417, pp. 1887-1888
DOI: 10.1126/science.131.3417.1887


The frequency of inagglutinable erythrocytes was increased in pigeons following total body irradiation and in human polycythemic patients treated with P32. Persistence of the increased levels of inagglutinable cells was observed in pigeons retested at over 200 days after irradiation and in a polycythemic patient retested at 173 days posttreatment. These data provide additional evidence for the mutational origin of the antigen-lacking cells.