Electronic Structure and Nicotine-like Stimulant Activity in Choline Phenyl Ethers

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Science  08 Jul 1960:
Vol. 132, Issue 3419, pp. 87-89
DOI: 10.1126/science.132.3419.87


Frontier electron density at the ether oxygen position and superdelocalizability at the ortho position show good parallelism with biological activity—that is, the stimulant activity of phenyl ether choline molecules. The mechanism of the biological action is discussed in connection with this finding.