Uterine Vascular Clamping: New Procedure for the Study of Congenital Malformations

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Science  08 Jul 1960:
Vol. 132, Issue 3419, pp. 89-91
DOI: 10.1126/science.132.3419.89-a


Clamping the uterine blood vessels of the rat on the 9th day of gestation for ½ to 3 hours resulted in fetal death, growth retardation, and severe congenital malformations. This procedure has broad applications in the fields of teratology and cancer chemotherapy, and in the investigation of fetal-maternal physiology.