Studies on the Regulation of Fatty Acid and Cholesterol Synthesis in Avian Liver

Science  12 Aug 1960:
Vol. 132, Issue 3424, pp. 418-419
DOI: 10.1126/science.132.3424.418


Homogenates of pigeon liver have been incubated with acetate-C14 in excess. Simultaneously, substrate for glycolysis was provided as glucose-6-phosphate. The incorporation of carbon-14 into cholesterol was maximal at low levels of glycolysis, whereas fatty acid turnover was maximum at higher glycolytic levels. A regulatory mechanism is proposed to explain the differential synthesis of cholesterol and fatty acids.