Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms

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Science  26 Aug 1960:
Vol. 132, Issue 3426, pp. 545-547
DOI: 10.1126/science.132.3426.545


A transmissible agent or factor has been found to be associated with all transplanted and spontaneous experimental tumors examined. This observation was made possible by utilization of a biochemical response of normal animals when inoculated with plasma or organ extracts from tumor-bearing hosts. This transmissible enzymic "lesion" is expressed by a five- to tenfold increase in the plasma lactic dehydrogenase activity of the injected normal test animals. The factor is heat labile, passes through bacteria-retaining filters, but is nondialyzable. It is partially sedimented by centrifugation at 100,000g for 1 hour.