Dehydrogenase Activities in Dystrophic Mice

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Science  02 Sep 1960:
Vol. 132, Issue 3427, pp. 621-622
DOI: 10.1126/science.132.3427.621


The levels of activity of glucose-6-phosphate dehydrogenase, isocitric dehydrogenase, glutathione reductase, lactic dehydrogenase, and a-glycerophosphate dehydrogenase have been studied in the gastrocnemius muscle of mice with "dystrophia muscularis." The activity of enzymes requiring triphosphopyridine nucleotide as a cofactor is increased relative to the control littermates, whereas the activity of those enzymes requiring diphosphopyridine nucleotide is decreased.