Poliovirus Inhibitor from the Central Nervous System of the Rhesus Monkey

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Science  02 Sep 1960:
Vol. 132, Issue 3427, pp. 622-623
DOI: 10.1126/science.132.3427.622-a


Suspensions from the central nervous system of rhesus monkeys inhibited the infection of monkey kidney cell cultures by types 1, 2, and 3 poliovirus, whereas inhibition of Coxsackie A9 and ECHO 12 viruses could not be readily demonstrated. Failure of suspensions of tissues of the central nervous system to irreversibly neutralize poliovirus indicated that the inhibition was not directed against the virus but affected viral multiplication by altering the host cells.