On the Reported Inhibition of Monoamine Oxidase by an Agent with Sedative Properties

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Science  16 Sep 1960:
Vol. 132, Issue 3429, pp. 735
DOI: 10.1126/science.132.3429.735


1-Benzyl-2-methyl-5-methoxytryptamine has been reported, on the basis of indirect evidence, to inhibit monoamine oxidase. More direct experiments, however, demonstrate that the drug is devoid of the ability to block monoamine oxidase in brain in vitro or in vivo.