Specific Inhibition of RHO(D) Antibody by Sialic Acids

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Science  11 Nov 1960:
Vol. 132, Issue 3437, pp. 1398-1399
DOI: 10.1126/science.132.3437.1398


Agglutination of RhO(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.