In vitro Organization of Single Beating Rat Heart Cells into Beating Fibers

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Science  16 Dec 1960:
Vol. 132, Issue 3442, pp. 1839-1840
DOI: 10.1126/science.132.3442.1839


Single, separate rat-heart cells in culture beat at different rates. When they grow into physical contact the beating becomes synchronous. Increase in cell number leads to the formation of beating, fiber-like masses. It appears that direct physical contact is necessary for attainment of synchronous contractions.