Photodynamic Inactivation of Infectious Nucleic Acid

Science  16 Dec 1960:
Vol. 132, Issue 3442, pp. 1840-1841
DOI: 10.1126/science.132.3442.1840


Tobacco mosaic virus-infectious nucleic acid causes a color shift when combined with acridine orange, methylene blue, and safranine. A high concentration of acridine orange inactivates infectious nucleic acid even in darkness, while a mixture of nucleic acid with a low concentration of the dye must be exposed to visible light prior to inoculation for inactivation to occur.