Excessive Stimulation of Salivary Gland Growth by Isoproterenol

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Science  06 Jan 1961:
Vol. 133, Issue 3445, pp. 44-45
DOI: 10.1126/science.133.3445.44


In the rat, chronic treatment with isoproterenol can cause a selective growth of the salivary glands to approximately five times their normal size within 17 days. This enlargement is principally due to mitotic proliferation and hypertrophy of the parenchymatous cells.