Facilitation of Infection of Monkey Cells with Poliovirus "Ribonucleic Acid"

Science  13 Jan 1961:
Vol. 133, Issue 3446, pp. 99-100
DOI: 10.1126/science.133.3446.99


The plaque titer of poliovirus "ribonucleic acid" on monkey kidney cells cultured in vitro is greatly increased by depleting these cells of calcium and treating the "ribonucleic acid" inoculum with a suspension of any one of several poorly water-soluble substances before inoculation. These undissolved substances apparently facilitate infection by serving as solid vehicles for the "ribonucleic acid."