Incorporation of Heterologous Deoxyribonucleic Acid into Mammalian Cells

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Science  10 Feb 1961:
Vol. 133, Issue 3450, pp. 381-382
DOI: 10.1126/science.133.3450.381


Particles containing large molecular heterologous deoxyribonucleic acid have been incorporated into strain L cells in suspension tissue culture. The particles are Feulgen-positive, they are fluorescent under ultraviolet light when stained with acridine orange, and they appear in both the nucleus and cytoplasm in radioautographic preparations.