Metabolism of Adrenaline after Blockade of Monoamine Oxidase and Catechol-O-methyltransferase

Science  24 Feb 1961:
Vol. 133, Issue 3452, pp. 586-587
DOI: 10.1126/science.133.3452.586


Experiments in cats infused with 5 µmole of dl-adrenaline-2-C14 showed that blockade of either monoamine oxidase or catechol-O-methyltransferase is largely compensated for by the activity of the intact enzyme system; combined blockade of both enzyme systems results in the formation of a new adrenaline catabolite and in the increased production of acidic, mainly conjugated, catabolites, the identity of which remains to be established.