Plaque Reduction, a Sensitive Test for Eastern Encephalitis Antibody

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Science  03 Mar 1961:
Vol. 133, Issue 3453, pp. 640-641
DOI: 10.1126/science.133.3453.640


Serologic surveys of vertebrates to determine rates of eastern encephalitis infection were made to discover the most likely disseminators of virus in nature. Of the techniques available, neutralization is the most specific, and antibody is known to persist for many years. This communication reports a fivefold increase in sensitivity of neutralizing-antibody detection by the application of a plaquereducing technique.