Rapid Effect of Sodium Cyanide and Dinitrophenol on Mammalian Nerve

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Science  24 Mar 1961:
Vol. 133, Issue 3456, pp. 876-877
DOI: 10.1126/science.133.3456.876-a


Strips of rat nerve from dorsal roots were immersed in solutions containing sodium cyanide and α-dinitrophenol. The inhibitors extinguish the action potential of such strips within minutes. The rapid action on mammalian nerve is contrasted with the slow effect of inhibitors on amphibian and invertebrate nerve.