Distinct "Feeding" and "Hunger Motivating" Systems in the Lateral Hypothalamus of the Rat

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Science  24 Mar 1961:
Vol. 133, Issue 3456, pp. 887-888
DOI: 10.1126/science.133.3456.887


Electrodes were implanted in the middle hypothalamus of rats to determine the neural organization of the "feeding" centers. Stimulations of the farand midlateral hypothalamic area produced feeding responses in sated animals, but only the former caused sated animals to cross an electrified grill to press a lever for food. After lesions had been made in the medial forebrain bundle, however, stimulations in the far-lateral hypothalamic area resulted in feeding in sated animals but failure to cross the electrical barrier to press a lever for food. Simultaneous far-lateral and "satiety" center stimulations produced feeding in sated animals but failed to "motivate" grill-crossing behavior.