Radioprotection by Mitotic Inhibitors and Mercaptoethylamine

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Science  24 Mar 1961:
Vol. 133, Issue 3456, pp. 888
DOI: 10.1126/science.133.3456.888


In the mouse, chemical interference with cellular proliferation alters the radiosensitivity of the bone marrow, and this results in protection from otherwise lethal x-irradiation. When intestinal damage is minimized by appropriate timing and dosage, many mitotic inhibitors increase radioresistance and enhance the protective effects of mercaptoethylamine.