Cellular Adaptation to Morphine in Rats

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Science  31 Mar 1961:
Vol. 133, Issue 3457, pp. 1018-1019
DOI: 10.1126/science.133.3457.1018


The respiration of KCl-stimulated cortical slices of brain from control rats is markedly depressed by morphine, whereas the respiration of those from rats chronically dosed with morphine is unaffected. The results demonstrate an adaptation to morphine at the cellular level which is concomitant with the adaptation of the whole animal to morphine