X-rays Affect the Incorporation of 5-Iododeoxyuridine into Deoxyribonucleic Acid

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Science  07 Apr 1961:
Vol. 133, Issue 3458, pp. 1074-1075
DOI: 10.1126/science.133.3458.1074


When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.